La Secretaría de Ciencia y Técnica de la FCM y el IHEM invitan a a un nuevo seminario en
el contexto del "Ciclo de Visitas Destacadas al IHEM".
En esta oportunidad disertará el Dr. Nicolas Blanchard,
quien está realizando una visita al IHEM en virtud de un proyecto de
cooperación bilateral Argentina-Francia.
El seminario se celebrará el día Jueves 23 de Abril a
las 11 h en la Sala de Seminarios del IHEM, edificio nuevo.
Resumen de la charla
Intravacuolar trafficking of T. gondii parasite
antigens critically influences their presentation by MHC I
Toxoplasma gondii,
target effectors to and across the boundary of their parasitophorous vacuole
(PV), resulting in host cell subversion and presentation by MHC class I
molecules for CD8 T cell recognition. The host-parasite interface comprises the
PV limiting membrane and a highly curved, membranous IntraVacuolar Network
(IVN) of uncertain function.
Using a combination of reverse genetics in the parasite,
in vitro tubulation assays and antigen presentation measurements, we dissected
how membrane tubules are shaped by the parasite effectors GRA2 and GRA6. We
showed that membrane association regulates immunogenicity of the GRA6
protective antigen in infected cells, suggesting that the IVN may play a role
in immune modulation.
Agendar